منابع مشابه
Apollo: a community resource for genome annotation editing
SUMMARY Apollo is a genome annotation-editing tool with an easy to use graphical interface. It is a component of the GMOD project, with ongoing development driven by the community. Recent additions to the software include support for the generic feature format version 3 (GFF3), continuous transcriptome data, a full Chado database interface, integration with remote services for on-the-fly BLAST ...
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MOTIVATION The massively parallel sequencing technology can be used by small research labs to generate genome sequences of their research interest. However, annotation of genomes still relies on the manual process, which becomes a serious bottleneck to the high-throughput genome projects. Recently, automatic annotation methods are increasingly more accurate, but there are several issues. One im...
متن کاملErrors in genome annotation.
A t the time that Watson and Crick proposed a structure for DNA, a visionary might have suggested that the complete genetic sequence of an organism would eventually be known. However, nobody could have realistically proposed that machines could automatically indicate gene functions. Yet precisely this has been achieved: with no laboratory experiments at all, the roles of most genes in several o...
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The concept of the gene plays a fundamental role both in the interpretation and in the organization and storage of molecular biology data. Genes are treated as if they were unambiguously characterized physical entities with clearly defined measurable properties. The ubiquitous usage of genes in current bio-databases reinforces this perception. A closer look at the data models and the ongoing di...
متن کاملComparative Genome Annotation Systems
Understanding the genetic content of a genome is a very important but challenging task. One of the most effective methods to annotate a genome is to compare it to the genomes that are already sequenced and annotated. This chapter is to survey systems that can be used for annotating genomes by comparing multiple genomes and discusses important issues in designing genome comparison systems such a...
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2019
ISSN: 1553-7358
DOI: 10.1371/journal.pcbi.1006790